团队成员

2022.9-2026.6 本科 吉林大学化学学院

2026.8-now 清华大学化学系

荣誉奖项：

2026年清华大学博士生未来学者奖学金

2017.9-2021.6 本科 南京大学化学化工学院

2021.8-2026.10 博士  清华大学化学系

荣誉奖项：

2026年综合优秀奖学金二等（清华之友-承德英才奖学金）

2024年综合优秀奖学金二等（清华之友-上海华谊奖学金）

2025年综合优秀奖学金三等（清华之友-绵阳科技城英才奖学金）

代表成果：     

· Yichun Wang, Yu Xia*, Deep profiling of plasmalogens by coupling the Paternò–Büchi derivatization with tandem mass spectrometry. Anal. Bioanal. Chem. 2024, 416(19): 4397-4407.

· Yichun Wang, Gaoge Sun, Hang Yin, Yu Xia*, Deep profiling reveals coordinated remodeling of ganglioside metabolism in MCF-7 breast cancer cell line. Chem. Sci.2026, 17: 6488-6499.

· Yichun Wang, Yu Xia*, Deep profiling of porcine brain gangliosides enabled by TiO2 magnetic nanoparticle-based enrichment and advanced lipidomic analysis. Analyst, 2026, 151(11): 3081-3090.

· Zidan Wang, Yichun Wang, Yu Xia*, Multi-structural profiling of neutral glycosphingolipids using selective enrichment and the Paternò–Büchi derivatization, Methods Enzymol.2026: 357-378.

· Shan-Le Wang, Kui Xiao, Yichun Wang, Yu Xia, Liang Zhao*, Single-atom synergy of luminescence and catalytic stability in silver-encapsulated gold nanoclusters. J. Am. Chem. Soc. 2026, 148(22): 22857-22866.

研究方向：基于富集与串联质谱的神经节苷脂深度分析及周转研究（PhD）

2016.9-2020.6 本科 兰州大学萃英学院

2020.8-2026.6 博士 清华大学化学系

荣誉奖项：

2022年基础课优秀助教一等奖

2024年综合优秀二等奖学金

2025年综合优秀一等奖学金

2025年博士生论坛口头报告一等奖

代表成果：

· Keting Zhou and Yu Xia*, High-Coverage Disulfide Mapping Enabled by Programmable Disulfide-Ene Reaction Integrated onto a Bottom-Up Protein Analysis Workflow. Anal. Chem. 2024, 96, 43, 17396–17404

· Keting Zhou, Xiaoyue Yang, Hanlin Ren, Yu Xia*, Visible-Light-Induced Disulfide Bond Reduction in Peptides and Proteins. J. Phys. Chem. A  2025, 129, 32, 7421–7428

· Keting Zhou and Yu Xia*, Bottom–Up Protein Analysis Workflow for Simultaneous Characterization of Payloads, Disulfide Bonds, and Free Thiols in Antibody–Drug Conjugates. Anal. Chem. 2025, 97, 51, 28132–28138

研究方向 (PhD thesis)：在线光化学衍生结合串联质谱法表征抗体药物二硫键连接方式

2015.9-2019.6 本科 复旦大学化学系

2019.9-2026.6 博士 清华大学化学系

荣誉奖项：

2022年清华大学综合一等奖学金

2021-2022学年度清华大学优秀研究生党建与思想政治工作者(党支部书记)

代表成果：

· Jian R J, Zhao X, Lin Q H, Xia Y*. Profiling of branched-chain fatty acids via nitroxide radical-directed dissociation integrated on an LC-MS/MS workflow. Analyst, 2022, 147(10):2115-2123.

· Jian R J, Wang S Z, Qiao L P, Zhao X*, Xia Y.* Profiling of Low-Abundance Branched-Chain Fatty Acids via Radical Directed Dissociation Tandem Mass Spectrometry. J Am Soc Mass Spectrom, 2026, 37(3), 782-789.

· 简瑞君; 瑕瑜*. 自由基化学-串联质谱用于脂质精细结构解析的研究进展. 质谱学报 2024, 45 (1):57-68.

研究方向 (PhD thesis)：化学衍生-自由基导向解离质谱技术解析脂质精细结构

2015.9-2019.6 本科 兰州大学萃英学院

2019.8-2025.6 博士 清华大学化学系

代表成果：

· Hengxue Shi, Zhenshu Tan, Xiangyu Guo, Hanlin Ren, Shengzhuo Wang, Yu Xia*. Visible-Light Paternò–Büchi Reaction for Lipidomic Profiling at Detailed Structure Levels. Anal. Chem., 2023, 95, 5117–5125.

· Hengxue Shi, Yu Xia*. Shotgun Lipidomic Profiling of Sebum Lipids via Photocatalyzed Paternò–Büchi Reaction and Ion Mobility-Mass Spectrometry. Anal. Chem., 2024, 96, 5589–5597.

· Hengxue Shi, Huijiao Bai, Haiteng Deng, Yu Xia*. Revealing Acyl Chain Selectivity of Cis-to-Trans Isomerase through Profiling  of C=C Geometry and Location Isomers of Bacterial Lipids. Anal. Chem., 2025, 97, 10378–10387.

目前去向：

百济神州（苏州）

2013.9-2017.6 本科 清华大学

2017.8-2023.6 博士 清华大学精密仪器系

代表成果：

· Donghui Zhang, Qiaohong Lin, Tian Xia, Jing Zhao, Wenpeng Zhang, Zheng Ouyang*, Yu Xia*. LipidOA: A Machine-Learning and Prior-Knowledge-Based Tool for Structural Annotation of Glycerophospholipids. Anal. Chem. 2022, 94, 48, 16759–16767.